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. Author manuscript; available in PMC: 2024 Nov 5.
Published in final edited form as: Nat Struct Mol Biol. 2024 Mar 27;31(5):810–816. doi: 10.1038/s41594-024-01236-3

Fig. 4: The decoding center stabilizes L34 at the wobble position.

Fig. 4:

a, Upon decoding of the cognate AUA codon, the universal nucleotide G530 in helix h18 stacks with L34 of Ile-tRNAIleLAU bound in the A/T conformation. b, The near-cognate AUG codon weakens the interactions with the decoding center, evidenced by the gap between G530 and L34 in structure II. c, Water-mediated interactions (gray dashed lines) between L34 of Ile-tRNAIleLAU in structure I and the G530 loop in the decoding center. The putative water ‘W’ is shown as a yellow sphere.