TABLE 1.
The microRNA regulating chondrocyte autophagy in OA.
|
microRNA |
microRNA expression | Affected tissue | Target/Signaling pathway | Results |
|---|---|---|---|---|
| miR-128a (Lian et al., 2018) | Upregulated | Human OA cartilage and cartilage of OA rat | Atg12 | Autophagy ↓ Apoptosis ↑ ECM degradation↑ |
| miR-375 (Li et al., 2020a) | Upregulated | Human OA cartilage, cartilage of OA mouse and miRNA-375 mimics transfected chondrocytes | ATG2B | Autophagy ↓ Endoplasmic reticulum stress ↑ |
| miR-378 (Feng et al., 2022) | Upregulated | Human OA cartilage and cartilage of miR-378 transgenic mice | ATG2A; SOX6 | Autophagy ↓ BMSC chondrogenic differentiation↓ |
| miR-20 (He and Cheng, 2018) | Upregulated | Human OA cartilage and IL-1β induced OA chondrocyte | ATG10; PI3K/AKT/mTOR axis | Autophagy ↓ Cell proliferation ↓ Inflammation ↑ |
| miR-155 (D’Adamo et al., 2016) | Upregulated | Human primary chondrocytes | Autophagy-related proteins | Autophagy ↓ |
| miR-155 (Liu et al., 2022) | Upregulated | Polychlorinated biphenyls reduced OA chondrocyte | RICTOR/Akt/mTOR signaling | Autophagy ↓ ECM degradation↑ |
| miR-302d-3p (Wang et al., 2019) | Upregulated | Human OA cartilage and miR-302d-3p mimics transfected chondrocytes | ULK1 | Autophagy ↓ Cell proliferation ↓ Apoptosis ↑ Inflammation ↑ |
| miR-30b (Chen et al., 2016) | Upregulated | TNF-α induced OA chondrocyte | BECN1 and ATG5 | Autophagy ↓ Apoptosis ↑ ECM degradation↑ |
| miR-7-5p (Zhao et al., 2023a) | Upregulated | Cartilage of OA rat and IL-1β induced OA chondrocyte | ATG4A | Autophagy ↓ ECM degradation↑ |
| miR-34a-5p (Wang et al., 2024a) | Upregulated | Developmental dysplasia of the hip reduced OA | SESN2; AMPK/mTOR axis | Autophagy ↓ Cell proliferation ↓ cell migration ↓ |
| miR-667-5p (Zeng et al., 2021) | Upregulated | Cartilage of OA rat and IL-1β induced OA chondrocyte | Ghrelin | Autophagy ↓ ECM degradation↑ |
| miR-4262 (Sun et al., 2018) | Upregulated | TNF-α induced OA chondrocyte | SIRT1; PI3K/AKT/mTOR axis | Autophagy↓ Apoptosis↑ Cell viability↓ |
| miR-140-5p/miR-149 (Wang et al., 2018a) | Downregulated | Human OA cartilage and IL-1β induced OA chondrocyte | FUT1 | Autophagy ↓ Apoptosis ↑ Cell proliferation ↓ |
| miR-373 (Zhang et al., 2021b) | Downregulated | Human OA cartilage and oxidative stress inducer tert-butyl hydroperoxide induced OA chondrocyte | miR-373/METTL3/TFEB axis | Autophagy ↓ Apoptosis ↑ |
| miR-145 (Tian et al., 2024) | Downregulated | Human OA cartilage | PI3K/Akt/mTOR axis | Autophagy ↓ Cell viability↓ |
| miR-199-3p (Yan et al., 2024) | Downregulated | cartilage of OA mouse and OA chondrocytes | TCF4 | Autophagy ↓ Apoptosis ↑ Inflammation ↑ |
| miR-146a (Chen et al., 2017) | Upregulated | Hypoxia-induced primary chondrocytes | Traf6/IRAK1/Bcl-2 axis | Autophagy ↑ ECM degradation ↓ |
| miR-335-5p (Zhong et al., 2019) | Downregulated | Human OA cartilage | miR-31-5p/SOX4/ERK/mTORC1 axis | Autophagy ↓ Cell proliferation ↓ Apoptosis ↑ Inflammation ↑ |
| miR-31-5p (Xu et al., 2022a) | Downregulated | Human OA cartilage and IL-1β induced OA chondrocyte | miR-31-5p/SOX4/ERK/mTORC1axis | Autophagy ↓ Cell proliferation ↓ Apoptosis ↑ |
| miR-766-3p (Li et al., 2020b) | Downregulated | IL-1β induced OA chondrocyte | miR-766-3p/AIFM1 axis | Autophagy ↓ Apoptosis ↑ ECM degradation↑ |