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. 2024 Oct 23;15:1464858. doi: 10.3389/fimmu.2024.1464858

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Copyright © 2024 Meng, Zhang, Xu, Ding, Yu and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structural virulence factors in Salmonella and pyroptosis. Salmonella flagellar protein FliC induces pyroptosis in human and murine macrophages by the NLRP3 inflammasome, but YdiV inhibits the expression of FliC preventing pyroptosis through the FlhD4C2 transposon. FljB induces pyroptosis in human and murine macrophages by activating the NLRC4 inflammasome. The deficiency of fepE in Salmonella Paratyphi A can activate caspase-4 and induce pyroptosis in THP- 1 macrophages.