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. 2024 Oct 23;15:1480594. doi: 10.3389/fimmu.2024.1480594

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Copyright © 2024 Venetsanopoulou, Ntinopoulou, Papagianni, Koletsos, Voulgari and Chrysanthopoulou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inflammatory markers are detected in the circulation of patients with rheumatoid arthritis-interstitial lung disease (RA-ILD). Levels of (A) CitH3 representing NET release, (B) thrombin anti-thrombin (TAT) complex and (C) interleukin (IL)-17A in the serum or plasma of patients with RA-ILD, compared to healthy individuals (HI) (n = 9 subjects per group). Correlation between (D) TAT and CitH3 levels or (E) IL-17A and CitH3 levels. Spearman’s r and P values are shown. Levels of (F) soluble terminal complement complex sC5b-9 in the plasma of patients with RA-ILD, compared to healthy individuals (HI) (n = 9 subjects per group). For (A, B, C, F), data are shown as mean ± SD, Mann-Whitney U test (two-tailed). All conditions were compared to HI. Statistically significant: P < 0.05.