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. 2024 Nov 5;14:26820. doi: 10.1038/s41598-024-77694-y

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© The Author(s) 2024, corrected publication 2024

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Fig. 6 — RNASET2 in RA patients. (A) Sections from human synovial tissue affected by RA and stained as labelled (a-c): synovitis characterized by high inflammatory infiltrate (a); RNASET2 expression found in CD163⁺ macrophages (b) and in CD66b⁺ neutrophils (c). Magnification: 100x, scale bar 200 μm (a); 600x, scale bar 33 μm (b-c). (B) Serum levels of RNASET2 in patients (RA) (n = 109) and controls (HC) (n = 53) detected by ELISA assay. ****p < 0.0001 by Mann Whitney U test. (C) Serum levels of IL-6 in patients (RA) (n = 109) and controls (HC) (n = 53) detected by ELISA assay. ***p = 0.0002 by Mann Whitney U test. (D) Correlation between IL-6 and RNASET2 by Spearman test (p = 0.04349).