Skip to main content
Biochemical Journal logoLink to Biochemical Journal
. 1982 Nov 1;207(2):329–332. doi: 10.1042/bj2070329

Appendix: Synthesis of N-acylglutathione derivatives by dimethylaminopyridine catalysis

Claudius D'Silva 1, Amina Al-Timari 1, Kenneth T Douglas 1
PMCID: PMC1153864  PMID: 7159386

Abstract

A general procedure, involving 4-dimethylaminopyridine-catalysed acylation of the amino groups in the appropriate S-blocked glutathione, is reported for the preparation of N-blocked derivatives of glutathiones.

Full text

PDF
329

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Douglas K. T., Al-Timari A., D'Silva C., Gohel D. I. Role of the N-terminus of glutathione in the action of yeast glyoxalase I. Biochem J. 1982 Nov 1;207(2):323–329. doi: 10.1042/bj2070323. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Hixson S. H., Hixson S. S. P-Azidophenacyl bromide, a versatile photolabile bifunctional reagent. Reaction with glyceraldehyde-3-phosphate dehydrogenase. Biochemistry. 1975 Sep 23;14(19):4251–4254. doi: 10.1021/bi00690a016. [DOI] [PubMed] [Google Scholar]
  3. Hög J. O., Holmgren A., D'Silva C., Douglas K. T., Seddon A. P. Glutathione derivatives as inhibitors of glutaredoxin and ribonucleotide reductase from Escherichia coli. FEBS Lett. 1982 Feb 8;138(1):59–61. doi: 10.1016/0014-5793(82)80394-3. [DOI] [PubMed] [Google Scholar]
  4. Kovacs J., Kalita C., Ghatak U. R. Synthesis of polyglutathione, polyasparthione, and related sequential polypeptides. J Org Chem. 1972 Jan 14;37(1):30–34. doi: 10.1021/jo00966a008. [DOI] [PubMed] [Google Scholar]
  5. Seddon A. P., Bunni M., Douglas K. T. Photoaffinity labelling by S-(p-azidophenacyl)-glutathione of glyoxalase II and glutathione S-transferase. Biochem Biophys Res Commun. 1980 Jul 16;95(1):446–452. doi: 10.1016/0006-291x(80)90758-5. [DOI] [PubMed] [Google Scholar]
  6. Seddon A. P., Douglas K. T. A photoaffinity label derivative of glutathione and its inhibition of glyoxalase I. FEBS Lett. 1980 Feb 11;110(2):262–264. doi: 10.1016/0014-5793(80)80087-1. [DOI] [PubMed] [Google Scholar]
  7. UTZINGER G. E., STRAIT L. A., TUCK L. D. The oxidation of glutathione with formic acid and hydrogen peroxide. Experientia. 1963 Jun 15;19:324–327. doi: 10.1007/BF02150437. [DOI] [PubMed] [Google Scholar]
  8. Vince R., Daluge S., Wadd W. B. Studies on the inhibition of glyoxalase I by S-substituted glutathiones. J Med Chem. 1971 May;14(5):402–404. doi: 10.1021/jm00287a006. [DOI] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES