Surface representation of the computationally predicted surface pockets of PLpro. The three pockets are located on the other face of PLpro, opposite the active site. Pocket 1 is a cleft between the thumb and Ubl domains. Pocket 2 is a cavity between the palm, fingers, and thumb domains. Pocket 3 is a cleft between the palm and finger domains. The PLpro domains are colored as follows: purple, Ubl (residues 1–60); green, thumb (residues 61–176); blue, fingers (residues 177–238); and brown, palm (residues 239–315). The figure was produced using PyMOL Molecular Graphics System version 2.5.5 (Schrödinger LLC).