Table 1. Assessment protocol for the K-ROAD cohort.
| Assessment | PREMIER consortium: Hospital-based cohort | LLOD | SMC amyloid PET registry | |
|---|---|---|---|---|
| Neuropsychological test | ||||
| Baseline | SNSB | SNSB | SNSB | |
| MMSE | MMSE | MMSE | ||
| CDR | CDR | CDR | ||
| Follow-up | N/A | SNSB | SNSB or MMSE or CDR | |
| MMSE | ||||
| CDR | ||||
| Questionnaires | K-PSQI, MNA, BAI, K-AD9, STR short version, K-ECog, K-NMSS, EQ-5D, IPAQ, CGA-NPI | N/A | ||
| Brain MRI protocol | 3D T1 (required), FLAIR (optional) | 3D T1, FLAIR, DTI, resting fMRI (optional) | ||
| Amyloid PET | Florbetaben and flutemetamol | PiB, florbetaben and flutemetamol | ||
| Tau PET | N/A | N/A | THK or AV1451 PET | |
| Blood tests | WBC, RBC, Hb, Hct, PLT, ALT, AST, BUN, Cr, Glucose, HbA1C, HDL cholesterol, total cholesterol, LDL cholesterol, TG, TSH, FT4, Folate, Vitamin B12 | N/A | ||
| Blood collection protocol | DNA, plasma, serum | DNA, plasma, serum, PBMC | DNA, plasma, serum | |
K-ROAD: the Korea-Registries to Overcome Dementia and Accelerate Dementia Research, PREMIER: precision medicine platform for mild cognitive impairment based on multi-omics, imaging, evidence-based R&BD, LLOD: longitudinal/cohort study of patients with late onset dementia cohort, SMC: Samsung Medical Center, SNSB: Seoul Neuropsychological Screening Battery, MMSE: Mini-Mental State Examination, CDR: clinical dementia rating, K-PSQI: Korean version of the Pittsburgh Sleep Quality Index, MNA: Mini Nutritional Assessment, BAI: Beck Anxiety Inventory, K-AD9: Korean version of the Alzheimer's Disease 9 scale, STR: stress short version questionnaire, K-ECog: Korean version of the Everyday Cognition scale, K-NMSS: Korean version of the Non-Motor Symptoms Scale, EQ-5D: EuroQol 5-dimension, IPAQ: International Physical Activity Questionnaire, CGA-NPI: Comprehensive Geriatric Assessment-Neuropsychiatric Inventory, MRI: magnetic resonance imaging, 3D T1: three-dimensional T1-weighted imaging, FLAIR: fluid-attenuated inversion recovery, DTI: diffusion tensor imaging, fMRI: functional magnetic resonance imaging, PET: positron emission tomography, PiB: Pittsburgh compound B, THK: [Tau-specific tracer] THK series, AV1451: Tau tracer AV1451 (also known as Flortaucipir), WBC: white blood cell count, RBC: red blood cell count, Hb: hemoglobin, Hct: hematocrit, PLT: platelet count, ALT: alanine aminotransferase, AST: aspartate aminotransferase, BUN: blood urea nitrogen, Cr: creatinine, HDL: high-density lipoprotein, LDL: low-density lipoprotein, TG: triglycerides, TSH: thyroid-stimulating hormone, FT4: free thyroxine (T4), PBMC: peripheral blood mononuclear cell.