TABLE 1.
Demographic and clinical characteristics of the study population
| Characteristic | Value (n = 54) |
|---|---|
| Demographics | |
| Gestational age (wk), mean ± SD | 31.00 ± 2.74 |
| Postmenstrual age (wk), mean ± SD | 33.16 ± 2.77 |
| Postnatal age (d), median [IQR] | 13.00 (8.00,19.25) |
| Birth weight (g), mean ± SD | 1449.44 ± 496.73 |
| Current weight (g), mean ± SD | 1571.30 ± 503.81 |
| Gender (male), n (%) | 32(59.26) |
| BSA (m2) | 0.13 ± 0.03 |
| Apgar score at 1 min, median [IQR] | 8.00 (7.00, 9.00) |
| Apgar score at 5 min, median [IQR] | 9.00 (8.00, 9.25) |
| Infectious disease, n (%) | |
| Pneumonia | 53 (98.15) |
| Bloodstream infection | 48 (88.89) |
| Necrotizing enterocolitis | 5(9.26) |
| Suppurative meningitis | 1 (1.85) |
| Complications, n (%) | |
| Respiratory failure | 42 (77.78) |
| Respiratory distress syndrome | 29 (53.70) |
| Asphyxia | 15 (27.78) |
| Septic shock | 6 (11.11) |
| Pathogen, n (%) | 31 (57.41) |
| Coagulase-negative Staphylococcus | 27 |
| Enterococcus faecium | 3 |
| Staphylococcus aureus | 1 |
| Linezolid MIC values | |
| 1 mg/L | 14 (45.16) |
| 2 mg/L | 17 (54.84) |
| Laboratory values at baseline | |
| Hemoglobin (g/L), mean ± SD | 126.43 ± 20.90 |
| Platelet (109/L), mean ± SD | 197.65 ± 95.16 |
| Total bilirubin (μmol/L), median [IQR] | 81.36 (40.93, 136.94) |
| Albumin (g/L), median [IQR] | 31.95 (29.33, 34.43) |
| ALT(U/L), median [IQR] | 9.00 (5.75, 17.00) |
| Cr (μmol/L), mean ± SD | 40.55 ± 12.96 |
| CLcr (mL/min/1.73 m2), median [IQR] | 29.46 (24.79, 40.41) |