TABLE 4.

Population PK parameter estimates in the final model and bootstrap^a,b

Parameter (unit)	Full model			Bootstrap
	Estimate (shrinkage %)	CV%	95% CI	Median	95% CI
Structural model parameters
tvV(L)	0.783	4.749	0.709–0.857	0.787	0.712–0.869
θBSA-V (m2)	1.066	30.750	0.413–1.720	1.100	0.311–1.915
tvCL (L/h)	0.154	5.010	0.139–0.169	0.154	0.140–0.172
θBSA-CL (m2)	1.185	21.774	0.671–1.700	1.212	0.555–1.771
Inter-individual variability
ω2CL (%)	0.132 (5.838)	18.58	0.0914–0.172	0.129	0.0886–0.170
Residual variability
stdev0	1.120	13.183	0.826–1.415	1.052	0.635–1.341

^a TV, typical population value; CV, coefficient of variation; θ_BSA-V is the adjusting factor of the BSA on the V; θ_BSA-CL is the adjusting factor of the BSA on the CL; 95% CI, 2.5^th and 97.5^th percentile of the ranked bootstrap parameter estimate; V, volume of distribution; CL, clearance; ω inter-individual variation; stdev0, standard deviation.

^b Typical population for a 1.571 Kg neonate.