TABLE 5.

Summary of optimal dosage regimen simulation under different BSA levels

BSA (m2)	Dosage	Interval	% of patients by distribution of Cmin,ss (μg/mL)			% of patients by distribution of AUC0-24 (mg·h/L)
			<2 µg/mL	2–8	>8	≤ 80	80–300	≥ 300
0.11	5 mg/kg	q8h	22.5	70.3	7.2	1.8	88.4	9.8
	6 mg/kg	q8h	15.7	71.8	12.5	0.4	89.1	10.5
	7 mg/kg	q8h	11.3	70.1	18.6	0.2	70.3	29.5
	10 mg/kg	q12h	35.9	56.4	7.7	0.3	75.0	24.7
	11 mg/kg	q12h	31.6	59.3	9.1	0.2	65.1	34.7
	12 mg/kg	q12h	29.5	58.8	11.7	0	55.7	44.3
0.13	6 mg/kg	q8h	24.0	69.8	6.2	2.3	88.1	9.6
	7 mg/kg	q8h	18.4	71.2	10.4	0.5	88.9	10.6
	8 mg/kg	q8h	14.5	69.6	15.9	0.3	77.2	22.5
	13 mg/kg	q12h	35.1	56.7	8.2	0.2	68.4	31.4
	14 mg/kg	q12h	31.3	58.5	10.2	0.1	60.4	39.5
	15 mg/kg	q12h	29.9	58.3	11.8	0	52.9	47.1
0.15	8 mg/kg	q8h	20.8	70.1	9.1	0.7	88.9	10.4
	9 mg/kg	q8h	16.5	70.5	13.0	0.3	89.0	10.7
	10 mg/kg	q8h	13.0	69.8	17.2	0.2	71.5	28.3
	17 mg/kg	q12h	31.6	58.1	10.3	0	58.0	42.0
	18 mg/kg	q12h	30.0	58.2	11.8	0	51.6	48.4
	19 mg/kg	q12h	29.1	57.5	13.4	0	46.0	54.0