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. 2024 Oct 21;21(14):2770–2780. doi: 10.7150/ijms.98246

Figure 2.

Figure 2

LCN2 depletion promoted liver injury in CLP-induced sepsis model. A septic mouse model was established by CLP and then LCN2 was knocked down by tail vein injection of Ad-shLCN2. The following experiments are carried out. (A) LCN2 mRNA levels were assessed by qRT-PCR in liver tissues of the control and CLP mice before and after LCN2 depletion. (B and C) Western blot and quantitative analysis of LCN2 protein expression in liver tissues of the control and CLP mice before and after LCN2 depletion. (D) H&E staining of liver tissues of the control and CLP mice before and after LCN2 depletion. (E-G) Serum ALT, AST, ALP levels were assessed by ELISA. (H-J) Liver ALT, AST, ALP levels were assessed by ELISA. Data were presented as mean ± SD (n = 5 per group). *p < 0.05, **p < 0.01, ***p < 0.001.