Table 2.
Association between SDF-1/CXCR4 genotypes and diabetic kidney disease.
| Variable | Non-diabetic kidney disease (N=335) | diabetic kidney disease (N=388) | AOR (95% CI) | p value |
|---|---|---|---|---|
|
SDF-1
rs1801157 |
||||
| Additive model | ||||
| GG | 175 (52.2%) | 176 (45.4%) | 1.000 (reference) | |
| GA | 139 (41.5%) | 180 (46.4%) | 2.242 (1.060-4.741) | p=0.035 |
| AA | 21 (6.3%) | 32 (8.2%) | 1.741 (0.441-6.875) | p=0.429 |
| Dominant model | ||||
| GG | 175 (52.2%) | 176 (45.4%) | 1.000 (reference) | |
| GA+AA | 160 (47.8%) | 212 (54.6%) | 2.156 (1.051-4.424) | p=0.036 |
|
SDF-1
rs2297630 |
||||
| Additive model | ||||
| GG | 267 (79.7%) | 303 (78.1%) | 1.000 (reference) | |
| GA | 60 (17.9%) | 75 (19.3%) | 0.583 (0.211-1.613) | p=0.299 |
| AA | 8 (2.4%) | 10 (2.6%) | 0.571 (0.052-6.274) | p=0.647 |
| Dominant model | ||||
| GG | 267 (79.7%) | 303 (78.1%) | 1.000 (reference) | |
| GA+AA | 68 (20.3%) | 85 (21.9%) | 0.581 (0.224-1.509) | p=0.265 |
|
SDF-1
rs2839693 |
||||
| Additive model | ||||
| CC | 263 (78.5%) | 296 (76.3%) | 1.000 (reference) | |
| CT | 68 (20.3%) | 87 (22.4%) | 1.832 (0.769-4.367) | p=0.172 |
| TT | 4 (1.2%) | 5 (1.3%) | 0.597 (0.029-12.144) | p=0.737 |
| Dominant model | ||||
| CC | 263 (78.5%) | 296 (76.3%) | 1.000 (reference) | |
| CT+TT | 72 (21.5%) | 92 (23.7%) | 1.712 (0.726-4.036) | p=0.219 |
|
SDF-1
rs266085 |
||||
| Additive model | ||||
| TT | 119 (35.5%) | 123 (31.7%) | 1.000 (reference) | |
| TC | 166 (49.6%) | 193 (49.7%) | 0.689 (0.319-1.488) | p=0.343 |
| CC | 50 (14.9%) | 72 (18.6%) | 1.150 (0.402-3.285) | p=0.794 |
| Dominant model | ||||
| TT | 119 (35.5%) | 123 (31.7%) | 1.000 (reference) | |
| TC+CC | 216 (64.5%) | 265 (68.3%) | 0.786 (0.384-1.608) | p=0.509 |
|
CXCR4
rs2228014 |
||||
| Additive model | ||||
| CC | 257 (76.7%) | 295 (76.0%) | 1.000 (reference) | |
| CT | 70 (20.9%) | 84 (21.6%) | 1.581 (0.667-3.745) | p=0.298 |
| TT | 8 (2.4%) | 9 (2.4%) | 1.845 (0.186-18.342) | p=0.601 |
| Dominant model | ||||
| CC | 257 (76.7%) | 295 (76.0%) | 1.000 (reference) | |
| CT+TT | 78 (23.3%) | 93 (24.0%) | 1.606 (0.703-3.671) | p=0.261 |
|
CXCR4
rs6430612 |
||||
| Additive model | ||||
| CC | 310 (92.5%) | 353 (91.0%) | 1.000 (reference) | |
| CT | 25 (7.5%) | 35 (9.0%) | 1.233 (0.370-4.110) | p=0.734 |
| TT | 0 (0.0%) | 0 (0.0%) | --- | --- |
| Dominant model | ||||
| CC | 310 (92.5%) | 353 (91.0%) | 1.000 (reference) | |
| CT+TT | 25 (7.5%) | 35 (9.0%) | 1.233 (0.370-4.110) | p=0.734 |
The adjusted odds ratio (AOR) with their 95% confidence intervals were estimated by multiple logistic regression models.