Table 3.
Association between SDF-1/CXCR4 genotypes and diabetic kidney disease with genetic allele model.
| Variable | Non-diabetic kidney disease (N=670) | diabetic kidney disease (N=776) | OR (95% CI) | p value |
|---|---|---|---|---|
|
SDF-1
rs1801157 |
||||
| Allele model | ||||
| G | 489 (73.0%) | 532 (68.6%) | 1.000 (reference) | |
| A | 181 (27.0%) | 244 (31.4%) | 1.239 (0.986-1.557) | p=0.065 |
|
SDF-1
rs2297630 |
||||
| Allele model | ||||
| G | 594 (88.7%) | 681 (87.8%) | 1.000 (reference) | |
| A | 76 (11.3%) | 95 (12.2%) | 1.090 (0.791-1.503) | p=0.598 |
|
SDF-1
rs2839693 |
||||
| Allele model | ||||
| C | 594 (88.7%) | 679 (87.5%) | 1.000 (reference) | |
| T | 76 (11.3%) | 97 (12.5%) | 1.117 (0.811-1.537) | p=0.499 |
|
SDF-1
rs266085 |
||||
| Allele model | ||||
| T | 404 (60.3%) | 439 (56.6%) | 1.000 (reference) | |
| C | 266 (39.7%) | 337 (43.4%) | 1.166 (0.945-1.438) | p=0.152 |
|
CXCR4
rs2228014 |
||||
| Allele model | ||||
| C | 584 (87.2%) | 674 (86.9%) | 1.000 (reference) | |
| T | 86 (12.8%) | 102 (13.1%) | 1.028 (0.756-1.398) | p=0.862 |
|
CXCR4
rs6430612 |
||||
| Allele model | ||||
| C | 645 (96.3%) | 741 (95.5%) | 1.000 (reference) | |
| T | 25 (3.7%) | 35 (4.5%) | 1.219 (0.722-2.058) | p=0.459 |