Table 4.
Association between SDF-1/CXCR4 genotypes and early diabetic kidney disease.
| Variable | Non-diabetic kidney disease (N=335) | Early CKD (N=308) | AOR (95% CI) | p value |
|---|---|---|---|---|
|
SDF-1
rs1801157 |
||||
| Additive model | ||||
| GG | 175 (52.2%) | 137 (44.5%) | 1.000 (reference) | |
| GA | 139 (41.5%) | 143 (46.4%) | 2.198 (1.036-4.663) | p=0.040 |
| AA | 21 (6.3%) | 28 (9.1%) | 1.721 (0.438-6.758) | p=0.436 |
| Dominant model | ||||
| GG | 175 (52.2%) | 137 (44.5%) | 1.000 (reference) | |
| GA+AA | 160 (47.8%) | 171 (55.5%) | 2.116 (1.029-4.353) | p=0.042 |
|
SDF-1
rs2297630 |
||||
| Additive model | ||||
| GG | 267 (79.7%) | 238 (77.3%) | 1.000 (reference) | |
| GA | 60 (17.9%) | 62 (20.1%) | 0.593 (0.215-1.633) | p=0.312 |
| AA | 8 (2.4%) | 8 (2.6%) | 0.614 (0.056-6.715) | p=0.689 |
| Dominant model | ||||
| GG | 267 (79.7%) | 238 (77.3%) | 1.000 (reference) | |
| GA+AA | 68 (20.3%) | 70 (22.7%) | 0.595 (0.230-1.544) | p=0.286 |
|
SDF-1
rs2839693 |
||||
| Additive model | ||||
| CC | 263 (78.5%) | 238 (77.3%) | 1.000 (reference) | |
| CT | 68 (20.3%) | 65 (21.1%) | 1.846 (0.774-4.402) | p=0.167 |
| TT | 4 (1.2%) | 5 (1.6%) | 0.613 (0.032-11.899) | p=0.746 |
| Dominant model | ||||
| CC | 263 (78.5%) | 238 (77.3%) | 1.000 (reference) | |
| CT+TT | 72 (21.5%) | 70 (22.7%) | 1.724 (0.731-4.066) | p=0.213 |
|
SDF-1
rs266085 |
||||
| Additive model | ||||
| TT | 119 (35.5%) | 105 (34.1%) | 1.000 (reference) | |
| TC | 166 (49.6%) | 146 (47.4%) | 0.693 (0.321-1.497) | p=0.350 |
| CC | 50 (14.9%) | 57 (18.5%) | 1.174 (0.410-3.362) | p=0.764 |
| Dominant model | ||||
| TT | 119 (35.5%) | 105 (34.1%) | 1.000 (reference) | |
| TC+CC | 216 (64.5%) | 203 (65.9%) | 0.793 (0.387-1.622) | p=0.525 |
|
CXCR4
rs2228014 |
||||
| Additive model | ||||
| CC | 257 (76.7%) | 232 (75.3%) | 1.000 (reference) | |
| CT | 70 (20.9%) | 68 (22.1%) | 1.591 (0.674-3.758) | p=0.289 |
| TT | 8 (2.4%) | 8 (2.6%) | 1.858 (0.196-17.595) | p=0.589 |
| Dominant model | ||||
| CC | 257 (76.7%) | 232 (75.3%) | 1.000 (reference) | |
| CT+TT | 78 (23.3%) | 76 (24.7%) | 1.618 (0.711-3.682) | p=0.252 |
|
CXCR4
rs6430612 |
||||
| Additive model | ||||
| CC | 310 (92.5%) | 276 (89.6%) | 1.000 (reference) | |
| CT | 25 (7.5%) | 32 (10.4%) | 1.173 (0.344-4.001) | p=0.799 |
| TT | 0 (0.0%) | 0 (0.0%) | --- | --- |
| Dominant model | ||||
| CC | 310 (92.5%) | 276 (89.6%) | 1.000 (reference) | |
| CT+TT | 25 (7.5%) | 32 (10.4%) | 1.173 (0.344-4.001) | p=0.799 |
The adjusted odds ratio (AOR) with their 95% confidence intervals were estimated by multiple logistic regression models.