Table 2.
Concordance Between RET-FISH and Other Molecular Techniques Performed on Lung Cancer Reported in the Literature: Cases Initially Screened by Another Method Where FISH Was Used as a Confirmatory/Validation Technique for the Chosen Screening Technique
| Study | Number of RET-FISH+ Samples Reported | Number of RET-FISH+ Samples Compared With Other Techniques | Number and % of Concordant Samples Between FISH and Other Techniques |
|---|---|---|---|
| Takeuchi et al.,36 2021 | 34 | 34 | 4 (100) [RT-PCR] 30 (100) [RNA-seq] |
| Yang et al.,23 2021 | 27 lung cancers (subset of the 171 samples with a RET structural variant) | 27 | 27 (100) [DNA-NGS] 25 (88.9) [RNA-seq] |
| Feng et al.,49 2022 | 25 | 25 | 25 (100) [RNA-seq] |
| Shang et al.,47 2019 | 20 | 20 | 20 (100) [RT-qPCR] |
| Yoh et al.,51 2017 | 19 | 19 | 19 (100) [RT-PCR] |
| Lira et al.,45 2014 | 15 | 15 | 15 (100) [NanoString] |
| Pan et al.,39 2014 | 15 | 15 | 15 (100) [RT-PCR] |
| Lee et al.,22 2015 | 14 | 14 | 14 (100) [NanoString] |
| Wang et al.,14 2012 | 13 | 13 | 13 (100) [RT-PCR] |
| Song et al.,37 2016 | 11 | 11 | 11 (100) [RT-PCR] 11 (100) [RNA-seq] |
| Chen et al.,48 2020 | 10 | 10 | 10 (100) [DNA-NGS] |
| Radonic et al.,30 2021 | 9 | 9 | 9 (100) [RNA-seq] |
| Kim et al.,40 2015 | 9 | 9 | 9 (100) [RT-PCR] |
| Kohno et al.,11 2012 | 6 | 6 | 6 (100) [RT-PCR] |
| Tanaka et al.,43 2017 | 4 | 4 | 4 (100) [RT-PCR] |
| Sokolova et al.,52 2020 | 3 | 3 | 3 (100) [validated method] |
| Sasaki et al.,35 2012 | 2 | 2 | 2 (100) [RT-PCR] |
| Reguart et al.,42 2017 | 2 | 2 | 2 (100) [NanoString] |
| Song et al.,41 2017 | 2 | 2 | 2 (100) [RT-PCR] |
| Ambrosini-Spaltro et al.,50 2022 | 2 | 2 | 2 (100) [RNA-seq] |
| Suehara et al.,44 2012 | 1 | 1 | 1 (100) [NanoString] |
| Borrelli et al.,38 2013 | 1 | 1 | 1 (100) [RT-PCR] |
| Velizheva et al.,46 2018 | 1 | 1 | 1 (100) [RNA-seq] |
DNA-NGS, DNA next generation sequencing; FISH, fluorescence in situ hybridization; RNA-seq, RNA-sequencing; RT-PCR, reverse transcription polymerase chain reaction; RT-qPCR, reverse transcription quantitative polymerase chain reaction.