Table 3.
Generalized linear mixed model analysis was conducted on cross-regional and non-cross-regional MDR-TB isolates
| Rv number | Gene | Position | SNP | Amino acid changes | P value | OR (95%CI) |
|---|---|---|---|---|---|---|
| Rv0239 | vapB24 | 289,179 | A76C | Thr26Pro | 1.000E + 00 | |
| Rv0298 | - | 363,464 | G213A | Arg71Arg | 0.999 | |
| Rv0300 | vapB2 | 363,996 | T171C | Gly57Gly | 0.999 | |
| Rv0657c | vapB6 | 753,562 | T56C | Ile19Thr | 1.000E + 00 | |
| Rv0662c | vapB7 | 755,873 | C151T | Arg51Cys | 0.835 | 0.847(0.485–11.204) |
| Rv0664 | vapB8 | 758,548 | G17T | Cys6Phe | 9.996E-01 | |
| Rv1246c | relE | 1,388,827 | A152T | Asn51Ile | 1.000E + 00 | |
| Rv1494 | mazE4 | 1,686,299 | T29G | Ile10Ser | 0.999 | |
| Rv1740 | vapB34 | 1,967,844 | C140A | Ala47Glu | 0.900 | 1.081(0.882–9.854) |
| Rv1943c | mazE5 | 2,195,025 | A323G | Glu108Gly | 0.999 | |
| Rv1955 | higB | 2,201,720 | T2C | Val1? | 0.080 | 2.274(3.878–24.336) |
| Rv1955 | higB | 2,201,808 | C90G | Asp30Glu | 9.997E-01 | |
| Rv1956 | higA | 2,202,491 | A354G | Ala118Ala | 9.998E-01 | |
| Rv1956 | higA | 2,202,500 | C363T | His121His | 0.999 | |
| Rv1956 | higA | 2,202,582 | G445T | Ala149Ser | 1.280E-04 | 6.347(221.676-1469.987) |
| Rv1959c | parE1 | 2,203,869 | G109A | Glu37Lys | 9.997E-01 | |
| Rv1959c | parE1 | 2,203,890 | C88T | Gln30* | 9.999E-01 | |
| Rv1960c | parD1 | 2,204,092 | C134T | Thr45Ile | 0.003 | 3.777(17.989-106.139) |
| Rv1962A | vapB35 | 2,205,451 | G99A | Lys33Lys | 0.003 | 7.057(326.409-4128.076) |
| Rv1962A | vapB35 | 2,205,511 | G39A | Thr13Thr | 9.996E-01 | |
| Rv1991A | mazE6 | 2,234,736 | G156A | Arg52Arg | 0.999 | |
| Rv2142c | parE2 | 2,402,439 | C72T | Asp24Asp | 0.999 | |
| Rv2274c | mazF8 | 2,546,684 | G122T | Gly41Val | 0.999 | |
| Rv2274c | mazF8 | 2,546,803 | G3A | Met1? | 0.999 | |
| Rv2526 | vapB17 | 2,851,303 | G213C | Glu71Asp | 0.999 | |
| Rv2547 | vapB19 | 2,868,659 | C54G | Ala18Ala | 0.747 | 1.155(1.324–7.603) |
| Rv2601A | vapB41 | 2,930,254 | G185A | Gly62Asp | 0.999 | |
| Rv2653c | - | 2,976,616 | C294G | His98Gln | 1.000E + 00 | |
| Rv2830c | vapB22 | 3,137,058 | C167T | Ala56Val | 0.998 | |
| Rv2862A | vapB23 | 3,174,748 | T2C | Ile1? | 0.978 | 0.97(0.298–23.36) |
| Rv2865 | relF | 3,177,660 | G124A | Ala42Thr | 0.439 | 0.539(0.359–8.194) |
| Rv2871 | vapB43 | 3,183,210 | A73G | Thr25Ala | 1.000E + 00 | |
| Rv3385c | vapB46 | 3,799,874 | G70A | Ala24Thr | 9.996E-01 | |
| Rv3407 | vapB47 | 3,826,316 | G65T | Arg22Leu | 0.999 | |
| Rv3407 | vapB47 | 3,826,501 | C250T | Arg84Cys | 4.660E-06 | 0.34(0.886–2.229) |
SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval