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. 2024 Oct 5;27(11):111102. doi: 10.1016/j.isci.2024.111102

Figure 5.

Figure 5

Overexpression of PKP2 improves cardiac function and reduces the incidence of AF

(A) Experimental flow chart. AAV-PKP2 virus was injected via tail vein for 4 weeks, MI model was established for 12 h, and related indexes were detected.

(B–D) Representative echocardiographic images and statistical data of EF (%), FS (%). NC: the empty AAV9 vector as a negative control for PKP2 overexpression (Sham, MI n = 8, +AAV-PKP2 n = 6, +AAV-NC n = 5 mice/group). +AAV-PKP2: MI+AAV-PKP2, +NC: MI+AAV-NC.

(E) LVIDd was detected by echocardiography.

(F) LVIDs was detected by echocardiography.

(G) Representative AF at 12 h after MI in mice detected by programmed electrical stimulation.

(H–K) Compared with Sham group, the incidence and duration of AF in mice were significantly increased after MI 12 h, which was significantly improved after injection of +AAV-PKP2 (Sham, MI n = 7 mice/group, +AAV-PKP2, +AAV-NC n = 6 mice/group). Data are presented as mean ± SEM. ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001. #p < 0.05, and ###p < 0.001. &&p < 0.01, and &&&p < 0.001 (One-way ANOVA).