Figure 1.

Experimental design, mouse physiology and multi-omics analysis

(A) Scheme of the experimental design.

(B) Five-hour fasted glycemia in Balb/c, C57Bl/6 and DBA/2 mice fed an RC or HFD. Each data point represents the mean ± SEM (n = 10–12 mice) glycemic level of the mice at 3, 10, and 30 days of diet feeding. Circles: RC fed mice; triangles: HFD fed mice.

(C) Correlation between 5-h fasted glycemia and the area under baseline of an insulin tolerance test. Each data point represents the mean ± SEM (n = 10–12 mice) for each time point, strain and feeding condition.

(D) Correlation between basal insulinemia and basal glycemia indicating no significant correlation. Each data point represents the mean ± SEM (n = 10–12 mice) for each time point, strain and feeding condition.

(E) Summary table of the number of mice, mouse groups, variables, and WGCNA modules for each each omics platform used and tissue analyzed.