Figure 3.

Pathways regulated with glycemia in pancreatic islets

(A) Plot showing the major KEGG pathways regulated with glycemia in pancreatic islets. The negative and positive NES values indicate, respectively, down- or up-expression of the indicated terms with glycemia. The colors indicate the p values of the enrichment score, and the size of the dots, the number of genes in each term.

(B) Illustration of the mRNAs that comprise selected KEGG terms with the color indication of their Z score value.

(C) Scheme of the major pathways down- (green) and up- (red) regulated with glycemia and that are involved in the control of β cell function.