Table 2.

Prediction model for menstruation recovery in all patients

	Univariate					Multivariable
	Estimate	HR	95% CI		P value	Estimate	HR	95% CI		P value	Points
Age at enrollment	-0.123	0.885	0.867	0.903	0.000
< 35	1.972	7.185	4.233	12.194	0.000	2.060	7.848	4.633	13.295	< 0.0001	5
35–39	1.521	4.577	2.769	7.566	0.000	1.600	4.951	3.005	8.157	< 0.0001	4
40–44	0.879	2.408	1.467	3.952	0.001	0.867	2.380	1.456	3.891	0.001	2
45		1			< 0.001		1			< 0.001	0
BMI	0.000	1.000	0.973	1.029	0.975
< 18.5	0.352	1.422	0.945	2.138	0.091
18.5–25		1			0.239
≥ 25	0.036	1.037	0.836	1.287	0.741
FSH < 30	0.711	2.036	1.500	2.763	0.000
E2 ≥ 40	0.980	2.665	1.801	3.946	0.000
Chemo-regimen
Anthracycline based	0.666	1.946	1.611	2.351	0.000	0.593	1.809	1.374	2.381	< 0.0001	1
Taxane based		1					1				0
5-FU	0.238	1.269	0.954	1.688	0.101
Herceptin	0.105	1.111	0.496	2.488	0.798
Chemo-duration
≤ 90 days	0.579	1.784	1.473	2.162	0.000	0.275	1.317	1.006	1.723	0.045	1
> 90 days		1					1				0

Abbreviations: BMI, body mass index; FSH, follicle-stimulating hormone; E2, estradiol; 5-FU, 5-fluorouracil;