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Antiplasmodial activity of artemisinin (ART) and its metabolite 10β–hydroxyartemisinin (ART-M) against two reference Plasmodium strains (Pf3D7 and PfDd2)
| Test drugs | Pf3D7 | PfDd2 | ||
|---|---|---|---|---|
| MIC50 (nM) | MIC90 (nM) | MIC50 (nM) | MIC90 (nM) | |
| CQ | 10.6 ± 2.8 | 16.3 ± 3.1 | 93.8 ± 9.9 | > 200.0 |
| ART | 10.1 ± 1.4 | 13.9 ± 0.5 | 20.4 ± 2.4 | 38.4 ± 0.9 |
| ART-M | 64.1 ± 8.8 | 103.0 ± 2.9 | 132.9 ± 5.5 | 209.8 ± 27.6 |
Chloroquine (CQ) was used as a positive model drug. No relevant MIC90 value was obtained for CQ against PfDd2
