Table 2.
The pharmacokinetic/pharmacodynamic indices for in vivo anti-malarial potency of artemisinin (ART) and its metabolite 10β-hydroxyartemisinin (ART-M)
| Parameter | ART | ART-M | ||
|---|---|---|---|---|
| Day-1 | Day-2 | Day-1 | Day-2 | |
| fCmax (nM) | 51.8 ± 18.0 | 43.1 ± 10.5 | 180.0 ± 72.2 | 175.0 ± 64.3 |
| fAUC0-t (nmol/L⋅h) | 155.6 ± 27.6 | 113.0 ± 20.1 | 799.3 ± 230.1 | 628.2 ± 217.7 |
| fCmax/MIC50 | 5.1 ± 1.8 | 4.3 ± 1.0 | 2.8 ± 1.1 | 2.7 ± 1.0 |
| fAUC0-t/MIC50 (h) | 15.4 ± 2.7 | 11.2 ± 2.0 | 12.5 ± 3.6 | 9.8 ± 3.4 |
| T > MIC50 (h) | 5.0 | 5.0 | 5.0 | 5.0 |
fCmax, maximum free plasma concentration; fAUC0-t, area under the free plasma concentration–time curve; MIC50, the 50% growth-inhibitory concentration against Pf3D7; T > MIC50, the time that free plasma concentration exceeds MIC50