Table 3.
Association between serum vitamin B12 level (pg/mL) and serum α-klotho (pg/mL) levels.
| Non-adjusted model | Model I | Model II | Model III | |||||
|---|---|---|---|---|---|---|---|---|
| β (95%CI) | P-value | β (95%CI) | P-value | β (95%CI) | P-value | β (95%CI) | P-value | |
| Vitamin B12 | 0.05 (0.03, 0.08) | <0.0001 | 0.05 (0.03, 0.08) | <0.0001 | 0.05 (0.02, 0.07) | 0.001 | 0.02 (−0.00, 0.05) | 0.0755 |
| Vitamin B12 quartile | ||||||||
| Q1 | Reference | Reference | Reference | Reference | ||||
| Q2 | 34.17 (11.15, 57.18) | 0.0036 | 34.61 (11.53, 57.69) | 0.0033 | 46.05 (20.62, 71.48) | 0.0004 | 48.71 (23.70, 73.73) | 0.0001 |
| Q3 | 42.42 (19.25, 65.59) | 0.0003 | 43.09 (19.82, 66.36) | 0.0003 | 53.36 (28.11, 78.61) | <0.0001 | 49.14 (24.02, 74.26) | 0.0001 |
| Q4 | 83.65 (59.67, 107.62) | <0.0001 | 84.27 (60.22, 108.31) | <0.0001 | 83.98 (57.98, 109.97) | <0.0001 | 68.90 (42.81, 94.99) | <0.0001 |
| P for trend | <0.0001 | <0.0001 | <0.0001 | <0.0001 | ||||
Adjust I model was adjusted for: gender; age, years (smooth); race. Adjust II model was adjusted for: model I + alcohol use; smoking status; sleep disorder; hypertension; diabetes; weak kidneys; asthma; congestive heart failure; coronary heart disease; COPD; thyroid problem; liver condition; stroke; gout; cancer or malignancy; BMI, kg/m2 (Smooth). Generalized additive models were applied. Adjust III model was adjusted for: model II + 25-hydroxyvitamin D3 (smooth); HDL (smooth); triglyceride (smooth); glucose (smooth); HbA1c (smooth); serum urate; eGFR (smooth); AST (smooth); ALT (smooth).