Table 4.
Threshold effect analysis of serum vitamin B12 (pg/mL) and serum α-Klotho (pg/mL) levels using piece-wise linear regression.
| Models | Total | Male | Female | |||
|---|---|---|---|---|---|---|
| β (95%CI) | P-value | β (95%CI) | P-value | β (95%CI) | P-value | |
| Model I | ||||||
| One line effect | 0.03 (0.01, 0.06) | 0.0195 | 0.04 (−0.00, 0.08) | 0.0749 | 0.02 (−0.01, 0.06) | 0.1919 |
| Model II | ||||||
| Inflection point (K) | 1020.00 | 1030.00 | 921.00 | |||
| <K | 0.14 (0.09, 0.18) | <0.0001 | 0.14 (0.07, 0.20) | <0.0001 | 0.15 (0.08, 0.21) | <0.0001 |
| >K | −0.12 (−0.17, −0.06) | <0.0001 | −0.11 (−0.19, −0.03) | 0.0069 | −0.11 (−0.18, −0.04) | 0.0015 |
| Model fit value at K | 948.94 (926.50, 971.38) | 954.83 (921.55, 988.11) | 939.77 (912.11, 967.43) | |||
| LRT test | <0.001 | <0.001 | <0.001 | |||
Models I and II represent one-dimensional linear regression and two-stage regression, respectively. Adjusted for: age; race; alcohol use; smoking status; sleep disorder; hypertension; diabetes; weak kidneys; asthma; congestive heart failure; coronary heart disease; COPD; thyroid problem; liver condition; stroke; gout; cancer or malignancy; BMI; 25-hydroxyvitamin D3; HDL; triglyceride; glucose; HbA1c; serum urate; eGFR; AST; ALT.