Table 4.
Results of GEE Models Adjusted for Age and Sex Comparing Electroretinography (ERG) Results in Eyes of People With Multiple Sclerosis Both With (MS +ON) and Without (MS −ON) Previous Optic Neuritis With Those of HC Participants
| Variable | Coefficient | Estimate | SE | 95% CI | P Value |
|---|---|---|---|---|---|
| DA0.01b.AMP | HC (intercept) | 440.04 | 35.24 | 370.96 to 509.12 | |
| MS −ON | 11.54 | 15.22 | −18.3 to 41.37 | 0.77 | |
| MS +ON | 18.97 | 16.49 | −13.34 to 51.28 | 0.55 | |
| DA0.01b.PEAK | HC (intercept) | 74.87 | 2.76 | 69.47 to 80.27 | |
| MS −ON | −0.55 | 1.17 | −2.84 to 1.75 | 0.81 | |
| MS +ON | 0.23 | 1.44 | −2.59 to 3.06 | 0.95 | |
| DA3.0a.AMP | HC (intercept) | −387.52 | 23.62 | −433.81 to −341.22 | |
| MS −ON | −0.43 | 10.31 | −20.63 to 19.78 | 0.97 | |
| MS +ON | −3.63 | 12.12 | −27.39 to 20.13 | 0.88 | |
| DA3.0a.PEAK | HC (intercept) | 14.04 | 0.27 | 13.51 to 14.57 | |
| MS −ON | 0.19 | 0.12 | −0.03 to 0.42 | 0.28 | |
| MS +ON | 0.30 | 0.13 | 0.05 to 0.54 | 0.089 | |
| DA3.0b.AMP | HC (intercept) | 589.10 | 43.26 | 504.32 to 673.89 | |
| MS −ON | 14.33 | 19.29 | −23.47 to 52.13 | 0.77 | |
| MS +ON | 29.22 | 20.48 | −10.91 to 69.36 | 0.37 | |
| DA3.0b.PEAK | HC (intercept) | 48.48 | 1.36 | 45.8 to 51.15 | |
| MS −ON | 2.10 | 0.67 | 0.78 to 3.42 | 0.014 | |
| MS +ON | 3.42 | 0.85 | 1.75 to 5.08 | 0.001 | |
| LA3.0a.AMP | HC (intercept) | −56.69 | 4.28 | −65.08 to −48.29 | |
| MS −ON | −1.32 | 1.94 | −5.13 to 2.48 | 0.77 | |
| MS +ON | −1.18 | 2.31 | −5.7 to 3.34 | 0.81 | |
| LA3.0a.PEAK | HC (intercept) | 13.60 | 0.26 | 13.08 to 14.12 | |
| MS −ON | 0.18 | 0.11 | −0.03 to 0.38 | 0.28 | |
| MS +ON | 0.08 | 0.16 | −0.23 to 0.39 | 0.81 | |
| LA3.0b.AMP | HC (intercept) | 259.44 | 19.42 | 221.39 to 297.5 | |
| MS −ON | 5.67 | 8.69 | −11.36 to 22.7 | 0.77 | |
| MS +ON | 2.67 | 9.24 | −15.44 to 20.78 | 0.88 | |
| LA3.0b.PEAK | HC (intercept) | 27.72 | 0.55 | 26.64 to 28.8 | |
| MS −ON | 0.36 | 0.24 | −0.11 to 0.82 | 0.35 | |
| MS +ON | 0.49 | 0.25 | −0.01 to 0.98 | 0.22 | |
| Flicker.AMP | HC (intercept) | 167.16 | 12.20 | 143.24 to 191.08 | |
| MS −ON | 4.25 | 5.17 | −5.88 to 14.37 | 0.77 | |
| MS +ON | 0.21 | 5.78 | −11.12 to 11.53 | 0.97 | |
| Flicker.PEAK | HC (intercept) | 23.78 | 0.71 | 22.39 to 25.16 | |
| MS −ON | 1.01 | 0.30 | 0.43 to 1.6 | 0.009 | |
| MS +ON | 1.09 | 0.36 | 0.39 to 1.79 | 0.014 |
AMP, response amplitude (in microvolts); CI, confidence interval; PEAK, response peak time (in milliseconds).
Corrected P values representing moderate, strong, or very strong evidence of a difference between the relevant MS subgroup and HC cohort are highlighted in bold (more details available in the Methods section and the Statistical Analysis subsection).