Table 5.

Results of GEE Models Analyzing the Influence of Multiple Sclerosis-Related Disability (EDSS), Disease Duration, Previous Optic Neuritis (ON), and Binarized Treatment Status on Selected ERC Peak Time Outcomes^*

Variable	Coefficient	Estimate	SE	95% CI	P Value
DA3.0b.PEAK	(Intercept)	53.41	2.36	48.75 to 58.04
	EDSS	−0.10	0.14	−0.38 to 0.17	0.57
	(Intercept)	53.14	2.14	48.94 to 57.33
	DD (years)	0.06	0.04	−0.02 to 0.15	0.41
	(Intercept)	51.88	2.14	47.70 to 56.07
	ON (yes)	1.22	0.85	−0.45 to 2.89	0.40
	(Intercept)	51.75	2.82	46.23 to 57.27
	Treated (yes)	0.85	1.26	−1.61 to 3.32	0.57
LA3.0b.PEAK	(Intercept)	28.11	0.84	26.47 to 29.75
	EDSS	0.02	0.06	−0.09 to 0.13	0.71
	(Intercept)	28.31	0.76	26.82 to 29.79
	DD (years)	0.02	0.02	−0.02 to 0.05	0.56
	(Intercept)	28.13	0.73	26.70 to 29.57
	ON (yes)	0.11	0.12	−0.13 to 0.36	0.56
	(Intercept)	27.19	1.00	25.24 to 29.14
	Treated (yes)	0.83	0.54	−0.22 to 1.88	0.41

CI, confidence interval; DA, dark adapted; DD, disease duration; EDSS, expanded disability status scale; LA, light adapted.

^*(dark- and light-adapted 3.0 b-wave peak times). For each model, the intercept is the expected value with all predictors as zero, with the estimate quantifying the expected change to the intercept when increasing EDSS by 1.0, DD by 1 year, or changing ON history and treatment status from no to yes, respectively, with all other factors remaining constant.