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. 2024 Nov 1;13(1):2419686. doi: 10.1080/2162402X.2024.2419686

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 4. — Gene expression of B7-H3 in a panel of ccRCC samples.

a) Gene expression of B7-H3 in a panel of ccRCC samples showed higher B7-H3 mRNA expression in IHC-scored B7-H3 high tumors vs. B7-H3 low tumors. No differences were observed in negative and positive controls. b) Volcano plot of B7-H3 differential expression in positive vs. baseline negative. Volcano plot displaying each gene’s −log10 (p-value) and log2 fold change with the selected covariate. The 40 most statistically significant genes are labeled in the plot. Genes also showed in Figure 4c are colored: top 4 higher expression in B7-H3 high tumor samples (IRS1, MMP14, CSF1R and JAK3) in red and top 4 lower in B7-H3 high tumor samples (GK, ALDH1A1, BMP2, and HAVCR2/TIM3) in blue. c) Gene expression of up- and down-regulated genes. Up-regulated genes in B7-H3 high tumors are shown in red box: IRS1, MMP14, CSF1R and JAK3; and downregulated genes in blue box: GK, ALDH1A1, BMP2 and HAVCR2/TIM3. Values are in log2 scale. d) B7-H3 co-expression analysis was identified from the ccRCC dataset from TCGA (Nature 2013; mRNA expression (log2); RNA Seq V2 RSEM; 417 samples) (32) using cBioportal (https://www.cbioportal.org/). R: Spearman, p values are included. All data are shown on log2.