Table 3.

Correlation between clinical and pathological variables and B7-H3 protein expression in primary tumor and metastatic lesion in ccRCC.

Metastatic ccRCC		Primary Tumor			Metastatic Lesion
Characteristic			B7-H3 low/no	B7-H3 high		B7-H3 low/no	B7-H3 high
Patients		N=52	(N=29)	(N=23)	N=52	(N=37)	(N=15)
	Median follow-up time		ρ = -0.320 / p = 0.021			ρ = -0.030 / p = 0.834
	months	47.5	78	31.5	47.5	59.5	36
	Median age at surgery		ρ = -0.150 / p = 0.289			ρ = 0.140 / p = 0.322
	years	59	61	55	59	55.5	61
Sex			ρ = -0.112 / p = 0.430			ρ = 0.074 / p = 0.604
	Female	13	6	7	13	10	3
	Male	39	23	16	39	27	12
Age at surgery			ρ = -0.086 / p = 0.547			ρ = -0.102 / p = 0.476
	< 70 years	45	24	21	44	30	14
	> 70 years	6	4	2	6	5	1
Grade*			ρ = 0.312 / p = 0.026			ρ = 0.215 / p = 0.130
	Low	22	16	6	22	18	4
	High	29	12	17	29	18	11
Stage**			ρ = 0.151 / p = 0.287			ρ = 0.067 / p = 0.637
	Low	27	17	10	27	20	7
	High	25	12	13	25	17	8
Diameter***			ρ = 0.124 / p = 0.380			ρ = -0.122 / p = 0.389
	< 4 cm	7	5	2	7	4	3
	> 4 cm	45	24	21	45	33	12
Tumor necrosis			ρ = 0.358 / p = 0.009			ρ = 0.164 / p = 0.246
	No	24	18	6	24	19	5
	Yes	28	11	17	28	18	10
Sarcomatoid transformation			ρ = 0.322 / p = 0.021			ρ = - 0.016 / p = 0.911
	No	47	28	19	47	34	13
	Yes	4	0	4	4	3	1
Disease free survival			ρ = 0.272 / p = 0.051			ρ = - 0.122 / p = 0.389
	Yes	11	9	2	11	9	2
	No	41	20	21	41	28	13
Survival			ρ = 0.78 / p = 0.581			ρ = 0.017 / p = 0.904
	Alive	18	11	7	18	13	5
	Dead	34	18	16	34	24	10
Metastasis			ρ = 0.288 / p = 0.039			ρ = 0.031 / p = 0.829
	Metachronous	37	24	13	37	26	11
	Synchronous	15	5	10	15	11	4
Metastatic site
Lymph node			ρ = 0.064 / p = 0.654			ρ = 0.356 / p = 0.009
	No	40	23	17	40	32	8
	Yes	12	6	6	12	5	7
Endothelial tissue			ρ = - 0.194 / p = 0.169			ρ = -0.212 / p = 0.131
	No	26	12	14	26	16	10
	Yes	26	17	9	26	21	5
Soft tissue and sarcoma			ρ = 0.158 / p = 0.264			ρ = -0.099 / p = 0.483
	No	38	23	15	38	26	12
	Yes	14	6	8	14	11	3

* Fuhrman’s grade, low (G1/2) vs. high (G3/4); ** AJCC 2010 staging low (pT1/2) vs. high (≥pT3); *** tumor diameter, small (≤4 cm) vs. large (>4 cm).

Spearman correlation ρ/p = p value. Note that age, grade, and sarcomatoid transformation have 1 missing value.