Table 4.

Univariate and Multivariate analyses to predict overall survival of metastatic ccRCC patients.

Univariate Analysis metastatic ccRCC
Variable	Description	Point Estimate	95% Wald Confidence Limits		P-value Log-rank
Grade	Low vs high	1.241	0.578	2.666	0.580
Stage	Low vs high	1.080	0.507	2.301	0.842
Diameter	<4 cm > 4 cm	1.359	0.410	4.503	0.616
Tumor necrosis	No vs yes	2.424	1.109	5.295	0.026
Sarcomatoid transformation	No vs yes	2.547	0.573	11.315	0.219
Metastasis synchronicity	Metachronous vs Synchronous	0.228	0.099	0.522	<0.0005
Metastatic site Lymph node	No vs yes	1.291	0.520	3.207	0.582
Metastatic site Endothelial tissue	No vs yes	0.666	0.313	1.417	0.291
Metastatic site Soft tissue, sarcoma	No vs yes	1.337	0.600	2.978	0.478
B7-H3 primary	No vs yes	2.373	1.113	5.060	0.025
Multivariate Analysis
Variable	Description	Point Estimate	95% Wald Confidence Limits		P-value Cox
Tumor necrosis	No vs yes	1.876	0.791	4.451	0.154
Sarcomatoid transformation	No vs yes	0.459	0.092	2.300	0.344
Metastasis synchronicity	Metachronous vs Synchronous	0.217	0.084	0.563	0.002
B7-H3 primary	No vs yes	2.205	0.949	5.124	0.066
Multivariate Analysis (excluding sarcomatoid transformation)
Variable	Description	Point Estimate	95% Wald Confidence Limits		P-value Cox
Tumor necrosis	No vs yes	1.926	0.829	4.474	0.127
Metastasis synchronicity	Metachronous vs Synchronous	0.270	0.111	0.658	0.004
B7-H3 primary	No vs yes	1.854	0.817	4.205	0.140

Univariate and multivariate stepwise Cox proportional hazards test/point estimate = hazard ratio.