Table 3.

Age-standardized biliary tract cancer-related mortality rate and APC among US adults ≥25 years in 2018–2023

	Age-standardized mortality rate (per 100,000 persons)						Average APC (95% CI)
	2018	2019	2020	2021	2022	2023	2018–2023
Intrahepatic cholangiocarcinoma	2.97	3.04	3.04	3.31	3.22	3.49	3.1 (1.2, 4.9)*
Race and ethnicity
Non-Hispanic White	2.92	2.98	3.01	3.21	3.19	3.42	3.1 (1.8, 4.4)*
Non-Hispanic Black	3.03	2.82	3.07	3.30	3.37	3.48	3.8 (1.0, 6.6)*
Non-Hispanic Asian	3.52	3.97	3.47	4.12	3.54	3.97	1.3 (–4.0, 6.8)
Hispanic	3.08	3.34	3.11	3.51	3.32	3.84	3.5 (–0.3, 7.4)
Sex
Male	3.38	3.46	3.43	3.60	3.57	3.88	2.4 (0.7, 4.1)*
Female	2.80	2.69	2.73	3.04	2.94	3.18	2.9 (0.2, 5.7)*
Extrahepatic cholangiocarcinoma	0.37	0.37	0.37	0.40	0.38	0.37	0.4 (–1.5, 2.4)
Race and ethnicity
Non-Hispanic White	0.37	0.38	0.37	0.38	0.37	0.37	–0.0 (–1.1, 1.1)
Non-Hispanic Black	0.31	0.32	0.31	0.39	0.33	0.32	1.5 (–4.6, 7.9)
Non-Hispanic Asian	0.33	0.31	0.31	0.29	0.33	0.37	2.8 (–0.4, 6.1)
Hispanic	0.31	0.35	0.47	0.43	0.48	0.33	3.4 (–9.4, 18.0)
Sex
Male	0.41	0.42	0.44	0.46	0.42	0.41	0.0 (–2.8, 2.9)
Female	0.32	0.33	0.32	0.33	0.36	0.34	1.7 (–0.5, 4.0)
Gallbladder cancer	0.86	0.82	0.86	0.82	0.77	0.79	–1.9 (–3.8, –0.0)*
Race and ethnicity
Non-Hispanic White	0.73	0.67	0.70	0.69	0.64	0.65	–2.1 (–4.2, 0.0)
Non-Hispanic Black	1.33	1.44	1.48	1.31	1.19	1.26	–2.8 (–7.1, 1.7)
Non-Hispanic Asian	1.07	1.00	0.74	1.10	0.92	0.95	–1.2 (–11.0, 9.7)
Hispanic	1.20	1.27	1.36	1.00	1.15	1.26	–1.1 (–8.6, 7.1)
Sex
Male	0.63	0.61	0.64	0.60	0.57	0.57	–2.2 (–4.2, –0.2)*
Female	1.06	1.01	1.04	1.00	0.94	1.00	–1.6 (–3.7, 0.6)

APC, annual percentage change; CI, confidence interval.

^*P<0.05.