. 2024 Oct 11;4(1):189–199. doi: 10.1159/000541792

Table 3.

Kidney involvement at presentation in patients with primary ANCA-negative PIGN according to ANCA status

Study	ANCA status	sCr or eGFR	RRT needed, %	Proteinuria, g/day, or dipstick intensity, %	Nephrotic syndrome, %	Hematuria, %
Hedger et al. [6] (2000)	Positive	8.8 mg/dL	60	N/D	N/D	N/D
Hedger et al. [6] (2000)	Negative	9.7 mg/dL	56	N/D	N/D	N/D
Eisenberger et al. [14] (2005)	Negative	3.0 mg/dL	20	2.7	20	100
Hung et al. [7] (2006)	Positive	5.7 mg/dL	36	2.9	N/D	N/D
Hung et al. [7] (2006)	Negative	5.5 mg/dL	27	3.1	N/D	N/D
Chen et al. [8] (2007)	Positive	6.5 mg/dL	N/D	2.2 ^a	8.8 ^a	N/D
Chen et al. [8] (2007)	Negative	7.1 mg/dL	53.6	5.5 ^a	46.4 ^a	100
Villacorta et al. [9] (2016)	Positive	3.4 mg/dL	42.3	1 ^a	5.8	100
Villacorta et al. [9] (2016)	Negative	2.9 mg/dL	34.4	3.1 ^a	3.4	100
Shah et al. [10] (2016)	Positive	31.9 mL/min/1.73 m ^2a	26	N/D	N/D	92
Shah et al. [10] (2016)	Negative	16.6 mL/min/1.73 m ^2a	47	N/D	N/D	88
Lee et al. [15] (2016)	Positive	1.9 mg/dL	N/D	N/D	N/D	N/D
Lee et al. [15] (2016)	Negative	4.3 mg/dL	N/D	N/D	N/D	N/D
Córdova-Sánchez et al. [16] (2016)	Positive	PR3 2.4 mg/dL	PR3 40	PR3 2.3	PR3 2.9	N/D
	Positive	MPO 2.5 mg/dL	MPO 19	MPO 2.7	MPO 4.8	N/D
	Negative	3.1 mg/dL	33.3	4.3	0	N/D
Sharma et al. [11] (2016)	Positive	5.6 mg/dL	45.1	1.6	N/D	76.5
Sharma et al. [11] (2016)	Negative	7.6 mg/dL	57.6	1.9	N/D	81.8
Ronsin et al. [4] (2022)	Negative	4.5 mg/dL	21	2.5	28	91
Floyd et al. [12] (2023)	Positive	18 mL/min/1.73 m²	11	N/D	N/D	N/D
Floyd et al. [12] (2023)	Negative	14 mL/min/1.73 m²	28	N/D	N/D	N/D
Elahi et al. [13] (2024)	Positive	9.8 mg/dL	72.1	T 5.8, 1+ 11.7, 2+ 27.9, 3+ 46.2, 4+ 11.7 ^a	N/D	100
Elahi et al. [13] (2024)	Negative	8.4 mg/dL	65.2	T 0, 1+ 6.1, 2+ 19.7, 3+ 47, 4+ 27.3 ^a	N/D	100

To simplify the data in the tables, only the average or median value is shown, without including standard deviations.

N/D, not described; T, trace.

^aReported as a statistically significant difference (also in bold).