Table 1.
Study Population With Analyzable Baseline CVR and Follow-up MRI Scan (N = 163)
| Baseline | Change after 1 y | |
| Median number of days between index stroke and baseline visit | 63 (45, 77) | — |
| Median number of days between baseline and follow-up visits | 369 (360, 387) | — |
| Median age in years | 68.0 (56.2, 74.4) | — |
| Number of men and women (model denominator: female) | 111 (68%), 52 (32%) |
— |
| Median MAP in mm Hg | 105 (98,115) | — |
| Number of diabetes diagnosis (model denominator: no) | 32 (20%) | — |
| Number of hypertension diagnosis (model denominator: no) | 118 (72%) | — |
| Number of hypercholesterolemia diagnosis (model denominator: no) | 118 (72%) | — |
| Number of smokers (current, ever, never; model denominator: never) | 26 (16%), 63 (39%), 74 (45%) | — |
| Number of lacune strokes, number of cortical strokes | 66 (40%), 97 (60%) | — |
| Median WMH volume in mL | 8.04 (3.90, 18.89) | 0.32 (−0.48, 1.78) |
| Median WMH volume in %ICV | 0.506 (0.242, 1.140) | 0.019 (−0.029, 0.117) |
| Median number of lacunes | 1 (0, 3) | 0 (0, 0) |
| Median number of microbleeds | 0 (0, 0) | 0 (0, 0) |
| Median brain volume in ml | 1,089 (1,009, 1,179) | −15 (−27, −5) |
| Median brain volume in %ICV | 67.6 (64.5, 71.1) | −0.97 (−1.60, −0.34) |
| Median BG PVS volume in %ROIV | 4.89 (3.33, 6.07) | 0.24 (−0.34, 0.95) |
| Median CSO PVS volume in %ROIV | 3.31 (2.18, 5.22) | 0.32 (−0.12, 1.18) |
| Median total PVS volume in %ROIV | 3.66 (2.47, 5.41) | 0.36 (−0.12, 1.15) |
| Median NIHSS | 1 (0, 2) | 0 (−1, 0) |
| Median modified Rankin Scale | 1 (1, 1) | 0 (−1, 0) |
| Median MoCA | 25 (23, 27) | 1 (−1, 3) |
| Number and of patients with recurrent stroke/TIA or new infarcts between index stroke and 1-y follow-up visit | 47 (29%) | — |
| Median CVR in SGM in %/mm Hg | 0.171 (0.135, 0.207) | — |
| Median CVR in NAWM in %/mm Hg | 0.042 (0.033, 0.054) | — |
| Median CVR in WMH in %/mm Hg | 0.040 (0.025, 0.065) | — |
Abbreviations: BG = basal ganglia; CSO = centrum semiovale; CVR = cerebrovascular reactivity; ICV = intracranial volume; MAP = mean arterial pressure; MoCA = Montreal Cognitive Assessment; NAWM = normal-appearing white matter; NIHSS = NIH Stroke Scale; PVS = perivascular space; ROIV = volume of region-of-interest; SGM = subcortical gray matter; WMH = white matter hyperintensity.
Demographic, clinical, and neuroimaging variables are given in each row. The value of the variable at baseline is shown in the second column: nonbinary variables are reported as median (Q1, Q3) and binary and smoking variables as number (%). The change in the relevant variables after 1 year is given in the last column as median (Q1, Q3). The denominator of the binary and categorical variables, which are as independent variables in the linear regression models, are emphasized.