Figure 4. Correlations Between Brain-Age and Disease Duration Gaps and Regional Brain and Lesion Volumes.

In the upper row, plots show the correlations between brain-age gap values and cortical (A) and subcortical/lesion (B) volumes. In the bottom row, plots show the correlations between disease duration gap values and cortical (C) and subcortical/lesion (D) volumes. Shown are the Pearson correlation coefficients resulting from partial correlation analyses correcting for age, age², disease duration, sex, and estimated total intracranial volume. The cortex is parcellated according to the DKT atlas.²¹ BAG = brain-age gap; DD = disease duration.