Figure 6. Relationships Between Brain-Age and Disease Duration Gaps and Physical Disability.

In the upper row, scatterplots show the marginal effects on EDSS scores of the brain-age (A) and disease duration (B) gap metrics (regression models were corrected for the effects of age, age², disease duration, and sex). In the bottom row, scatterplots show the relationship between annualized changes in EDSS and brain-age (C) and disease duration (D) gaps. Linear fit lines are shown as solid lines (with corresponding 95% confidence intervals in gray). DD = disease duration; EDSS = Expanded Disability Status Scale.