Table 1.
Clinical trials of EV-based cancer therapies.
| Name | Institute | Cancer | Stage | NCT number |
|---|---|---|---|---|
| iExosomes | M.D. Anderson Cancer Center | Pancreatic cancer with KRAS-G12D mutation | Phase 1 | NCT03608631 |
| exoSTING | Codiak BioSciences | Advanced solid tumors | Phase 1/2 | NCT04592484 |
| exoASO-STAT6 | Codiak BioSciences | Advanced HCC and liver metastases | Phase 1 | NCT05375604 |
| DC-derived exosomes | Gustave Roussy, Cancer Campus | Non-small cell lung cancer | Phase 2 | NCT01159288 |
| Chimeric exosomal tumor vaccines | Fudan University Pudong Hospital | Recurrent or metastatic bladder cancer | Phase 1 | NCT05559177 |
| Plant exosomes | University of Louisville | Colon cancer | Phase 1 | NCT01294072 |
| Plant exosomes | University of Louisville | Head and neck cancer with oral mucositis | Phase 1 | NCT01668849 |
| UCMSC-Exo | Wuhan Union Hospital | Myelosuppression in acute myeloid leukemia | Phase 1 | NCT06245746 |