Table 4.

Summary of the treatment evidence targeting cognitive and other nonmotor symptoms in Huntington’s disease

Effective					No benefit					Conflicting
Class	I	II	III	IV	Class	I	II	III	IV	Class	I	II	III	IV
Dementia
					Level A					Level U
					Pridopidine	3				Latrepirdine	2
					Level B					Rivastigmine	1		1
					Donepezil	1				Gpi DBS		1	3	4
					Level C
					Citalopram		1
					Atomoxetine		1
					Fetal striatal grafting		1	1
					Cannabinoid (sativex)		1
Sleep
					Level C
					Pridopidine	1
Respiratory function
Level C
Home-based respiratory muscle training program		1

Therapies with undetermined evidence (U) for effective or no benefit domain were excluded from this table.

Gpi, globus pallidus interna; DBS, deep brain stimulation.