Table 2.

Reports on engineered bacterial therapeutics for tumor.

Chassis	Target disease	Genetically encoded biosensor	Actuator	Model	Refs
E. coli χ6212 Δasd	Tumor	-	α-hemolysin	BALB/c mice	[36]
E. coli MG1655	Tumor	-	Type 3 secretion system Mitochondrial targeting domain of Noxa	BALB/c mice	[37]
E. coli Nissle 1917 ΔdapA, thyA	Tumor	-	Cyclic di-AMP	C57BL/6 mice BALB/c mice	[38]
E. coli Nissle 1917 ΔargR, malEK::argAfbr	Tumor	-	L-Arginine	C57BL/6 mice	[39]
E. coli Nissle 1917	Tumor	-	Melanine	BALB/c mice	[40]
Pediococcus pentosaceus SL4 Δalr	Colorectal cancer	-	P8	BALB/c mice C57BL/6J mice	[42]
E. coli Nissle 1917	Colorectal cancer	Lactate, pH, Hypoxia-inducible sensor for the expression of serine integrase	Hemolysin	BALB/c mice C57BL/6J mice	[43]
E. coli Nissle 1917	Colorectal cancer	-	INP-tagged histone-like protein A YebF-fused I1 myrosinase	BALB/c mice	[44]
Bifidobacterium breve	Head and neck squamous cell carcinoma	-	MDA-7/IL-24	BALB/c mice	[49]
E. coli Pir1+	Tumor	AHL-inducible sensor for the production of transcription factor and lysis protein	Phage-lysis protein (ϕX174E) HA-tagged CD47 antagonistic nanobody	BALB/c mice C57BL/6 mice	[50]
E. coli Nissle 1917	Tumor		Phage-lysis protein (ϕX174E) HA-tagged PD-L1 blocking nanobody HA-tagged CTLA4 blocking nanobody Granulocyte-macrophage colony-stimulation factor	BALB/c mice	[51]
E. coli Nissle 1917 ΔclbA	Colorectal neoplasia			C57BL/6 mice	[52]