Table 3.

Reports on engineered bacterial therapeutics for metabolic disorder.

Chassis	Target disease	Genetically encoded biosensor	Actuator	Model	Refs
L. lactis	Obesity	-	GLP-1	C57BL/6 mice	[54]
L. reuteri	Nonalcoholic fatty liver disease	-	Interleukin-22	C57BL/6J mice	[60]
L. reuteri	Alcoholic liver disease	-	Interleukin-22	C57BL/6 mice	[61]
L. lactis	Diabetes	-	Proinsulin Interleukin-10	NOD mice	[62]
Lactobacillus paracasei	Diabetic retinopathy	-	Angiotensin converting enzyme 2	C57BL/6J mice	[63]
E. coli Nissle 1917 ΔthyA	Enteric hyperoxaluria	-	Oxalate/formate antiporter Oxalyl-CoA decarboxylase Formyl-CoA trasferase	C57BL/6J mice Cynomolgus monkey	[65]
E. coli Nissle 1917 ΔthyA, argR	Hepatic encephalopathy	-	N-acetylglutamate synthase	C57BL/6 mice Cynomolgus monkey Human (healthy)	[66]
E. coli Nissle 1917 ΔdapA	Phenylketonuria	-	Phenylalanine transporter Phenylalanine ammonia lyase L-amino acid deaminase	C57BL/6 mice Cynomolgus monkey	[67]
		Trans-cinnamate-inducible sensor for the screening of phenylalanine ammonia lyase activity	Phenylalanine transporter Phenylalanine ammonia lyase mutant L-amino acid deaminase	Cynomolgus monkey	[68]
		Small molecule-inducible sensor array for the regulation of enzyme expression		-	[69]