Table 5.

Reports on engineered bacterial therapeutics for other diseases.

Chassis	Target disease	Genetically encoded biosensor	Actuator	Model	Refs
L. lactis	Parkinson’s disease	-	GLP-1	C57BL/6 mice	[91]
E. coli Nissle 1917	Parkinson’s disease	Red-light inducible chimeric light sensor for production of cell lysis enzyme	Exendin-4 fused anti-neonatal FC receptor affibody	C57BL/6 mice	[92]
L. lactis	Antibiotic-induced dysbiosis	-	SpyTag fused β-lactamase fragment 1 SpyCatcher fused β-lactamase fragment 2	C57BL/6 mice	[93]