Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 May 9;29(11):3330–3343. doi: 10.1038/s41380-024-02576-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — A Postmortem brain samples from a human cohort with 268 participants were used, including 198 normal individuals (CTR), 45 patients with schizophrenia (SCZ), and 25 patients with bipolar (BP). B Deep brain proteome was profiled by 11-plex TMT-based proteomics, followed by extensive quality control and data analysis. Brain proteomic data and comparable genotype data were prepared for subsequent linkage analysis. C Genome-wide association analysis to identify genetic regulations of protein expression and gene expression. D Co-localization analysis to investigate the same variant underlying cis-eQTLs and cis-pQTLs. E Mediation analysis to identify transcript-dependent and -independent regulations and causality analysis to link eGenes and pGenes to SCZ GWAS loci. F Prioritization of proteins for SCZ GWAS loci.