Fig. 4. Co-localized QTLs modulating the expression levels of genes and proteins.

A Ternary plot showing colocalization posterior probabilities of QTLs of gene and protein expression. We considered H₀ + H₁ + H₂ as evidence for the lack of test power. H₀: no causal variant, H₁: causal variant for PD GWAS only, H₂: causal variant for QTL only, H₃: two distinct causal variants, H₄: one common causal variant. B Scatter plot showing the distribution of effect sizes of 76 matched SNP-eQTLs and SNP-pQTLs colocalized pairs. C LocusZoom plot showing a colocalized QTL regulating SRR gene and protein expression. D Box plot showing normalized SRR protein expression and its cis-pQTL allele dosage. E Box plot showing normalized SRR gene expression and its cis-eQTL allele dosage.