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. 2024 Aug 24;33(21):1858–1872. doi: 10.1093/hmg/ddae124

Figure 3.

Figure 3

Somatic indels in microsatellite repeats, determined from GangSTR genotype calls in 29 sporadic MSI and 11 LS CRCs. (A) The number of microsatellite repeat loci with insertions or deletions normalised by the total number of loci of each motif length. The x-axis separates microsatellite repeats with motif lengths from 1 to 6 in 226 MSS-CRCs as well as the MSI-CRCs. The y-axis is on a log scale. (B) The number of loci in dinucleotide repeats in active and repressed genomic regions with insertions or deletions. Counts normalised by the total number of loci in dinucleotide repeats for each annotation and shown as a percentage. Annotations are based on annotations from the roadmap epigenomics project. (C) The number of loci in dinucleotide repeats in protein-coding genes with insertions or deletions. Counts normalised by the total number of loci in dinucleotide repeats for each annotation and shown as a percentage. Annotations are based on GENCODE biotype annotations.