TABLE 2.

Three single nucleotide polymorphisms (SNPs) significantly associated with chronic Pseudomonas aeruginosa age at the genome-wide significance level

SNP	Chromosome	Effect allele	Reference allele	Sample	n	MAF	β# (95% CI) (years)	p-value
rs927553	13	G	C	CGMS	1037	0.44	1.51 (0.98–2.04)	1.91×10−8
				European	991	0.43	1.53 (0.98–2.07)	3.33×10−8
				Non-European	46	0.49	1.15 (−0.82–3.11)	0.25
				FCGS	501	0.45	0.05 (−0.68–0.77)	0.90
rs927552	13	G	A	CGMS	1037	0.41	1.51 (0.97–2.04)	3.64×10−8
				European	991	0.40	1.55 (1.00–2.11)	3.88×10−8
				Non-European	46	0.47	0.64 (−1.19–2.47)	0.49
				FCGS	501	0.41	0.01 (−0.71–0.73)	0.97
rs62369766	5	T	G	CGMS	1037	0.17	−2.00 (−2.70– −1.30)	1.98×10−8
				European	991	0.17	−1.96 (−2.68– −1.25)	7.13×10−8
				Non-European	46	0.10	−2.91 (−5.92–0.10)	0.06
				FCGS	501	0.17	−1.24 (−2.19– −0.30)	0.01

MAF: minor allele frequency. The genetic effects and p-values are provided, separately, for association analyses using 1) the combined sample of 1037 individuals in the Canadian CF Gene Modifier Study (CGMS), 2) 991 European individuals (including 52 sibling pairs) in CGMS, 3) 46 non-European individuals (including five sibling pairs) in CGMS and 4) 501 individuals in the independent French CF Modifier Gene Study (FCGS). The association analysis accounted for sample relatedness through the linear mixed effect model (supplementary appendix S1). ^#: effect estimate for each additional copy of the effect allele.