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. 2024 Nov 6;635(8037):201–209. doi: 10.1038/s41586-024-07861-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — (a) Heatmaps showing co-occurrences of ecDNA-amplified oncogenes in individual tumour samples (top) and co-occurrences of oncogenes on distinct ecDNA species in individual tumour samples (bottom). Genes are sorted based on their chromosomal locations. (b) Examples of reconstructions of co-occurring, distinct ecDNA species in a glioblastoma sample, a low-grade glioma sample, and a urothelial bladder carcinoma sample.