Fig. 2. APOE-RA improves motor learning in PAE mice.

a Pearson’s correlation analysis reveals a positive correlation (R² = 0.558, P = 0.0166) between the motor learning index and the number of APOE positive cells in the motor cortex in PAE mice (Supplementary Fig. 3). Each dot represents an individual animal (n = 8). Solid line indicates the best fit line. b Schematic shows a timeline of the APOE-RA treatment and behavioral tests. c PAE mice treated daily with APOE-RA for 10 days show significantly improved terminal speed in trial 6 in accelerated rotarod test compared to vehicle-treated PAE mice (control+vehicle: n = 9; control+APOE-RA: n = 10; PAE+vehicle: n = 7; PAE + APOE-RA: n = 10). ***P < 0.001 by two-way ANOVA with simple main effect test. Data represent mean ± s.e.m. d Postnatal APOE-RA treatment significantly improves motor learning index in PAE mice (control+ vehicle: n = 9; control+APOE-RA: n = 10; PAE+vehicle: n = 7; PAE + APOE-RA: n = 10). Box plot represents 25th, median, and 75th percentile. Whiskers extended to min and max values. **P < 0.01 by two-way ANOVA with simple main effect test. Data represent mean ± s.e.m.