Table 4.

Clinical Outcomes

Outcome / Valve position	No. patients with event (%)	Per 100 PY	Unadjusted HR (95% CI)	P value	Adjusted HR (95% CI)	P value
Composite outcome
Aortic	90 (15.3)	12.7	Ref.	–	Ref.	–
Mitral	25 (12.8)	10.2	0.80 (0.52–1.25)	0.333	0.89 (0.51–1.54)	0.669
Both	16 (14.4)	11.8	0.92 (0.54–1.57)	0.768	1.10 (0.58–2.09)	0.773
Stroke/systemic embolism
Aortic	14 (2.4)	1.90	Ref.	–	Ref.	–
Mitral	4 (2.1)	1.59	0.84 (0.28–2.56)	0.761	0.54 (0.13–2.13)	0.375
Both	4 (3.6)	2.90	1.55 (0.51–4.72)	0.437	0.50 (0.09–2.72)	0.424
Stroke
Aortic	12 (2.0)	1.62	Ref.	–	–	–
Mitral	3 (1.5)	1.19	0.74 (0.21–2.61)	0.637	–	–
Both	3 (2.7)	2.16	1.36 (0.38–4.80)	0.638	–	–
Systemic embolism
Aortic	2 (0.3)	0.27	Ref.	–	–	–
Mitral	1 (0.5)	0.40	1.49 (0.14–16.38)	0.747	–	–
Both	1 (0.9)	0.72	2.73 (0.25–30.06)	0.413	–	–
Major bleeding
Aortic	17 (2.9)	2.31	Ref.	–	Ref.	–
Mitral	1 (0.5)	0.40	0.17 (0.02–1.30)	0.088	0.14 (0.02–1.22)	0.075
Both	3 (2.7)	2.15	0.94 (0.28–3.21)	0.922	0.44 (0.09–2.32)	0.335
HF requiring hospitalization
Aortic	42 (7.1)	5.79	Ref.	–	Ref.	–
Mitral	18 (9.2)	7.32	1.26 (0.72–2.19)	0.415	1.73 (0.85–3.53)	0.131
Both	4 (3.6)	2.90	0.49 (0.18–1.37)	0.176	1.00 (0.34–2.96)	1.000
All-cause death
Aortic	33 (5.6)	4.42	Ref.	–	Ref.	–
Mitral	8 (4.1)	3.17	0.71 (0.33–1.54)	0.387	0.73 (0.29–1.83)	0.504
Both	6 (5.4)	4.30	0.97 (0.41–2.31)	0.938	1.19 (0.42–3.35)	0.749
BPV reoperation
Aortic	5 (0.9)	0.67	Ref.	–	–	–
Mitral	1 (0.5)	0.40	0.60 (0.07–5.13)	0.640	–	–
Both	1 (0.9)	0.72	1.08 (0.13–9.24)	0.945	–	–

BPV, bioprosthetic valve; CI, confidence interval; HF, heart failure; HR, hazard ratio; PY, patient-years.