Table 2.

Subset of Research Cases: 1–24 used for Figures; 1–48 used for TMEM106B Genotype at residue 185

Case	TMEM106B genotype	Birth sex	Age at death (Years)	Primary neuropathological diagnosis
1	TT	Female	81	Alzheimer disease, Sporadic	1a,1b,1e,1f
2	SS	Female	81	Alzheimer disease, Sporadic	S1a,S1b
3	TT	Female	87	Alzheimer disease, Sporadic	1c,1d,1 g,1 h,2a,2b,2e,2f,3,5a, 9
4	TS	Female	82	Alzheimer disease, Sporadic	S2a,S2b,S2c,S2d
5	TS	Female	96	Alzheimer disease, Sporadic	2 g,2 h
6	TT	Male	67	FTLD-TDP Type A (GRN), Hereditary	4c
7	TS	Female	93	Alzheimer disease, Sporadic	4d
8	TS	Female	97	Alzheimer disease, Sporadic	4e,5b,6,8a,S6
9	TT	Female	63	FTLD-Tau, Hereditary	4a
10	TT	Female	67	Alzheimer disease, Dominantly Inherited	4b
11	TT	Male	93	Alzheimer disease, Sporadic	7,S7a,S7b,S8a,S8b
12	TT	Female	70	Alzheimer disease, Sporadic	3
13	TT	Female	68	Alzheimer disease, Sporadic	3
14	TT	Male	61	Alzheimer disease, Sporadic	3,9
15	TS	Male	87	Diffuse Lewy body disease	3
16	TT	Female	91	Alzheimer disease, Sporadic	3
17	TT	Male	70	Alzheimer disease, Sporadic	3
18	TT	Male	57	Alzheimer disease, Sporadic	3
19	TT	Female	70	Alzheimer disease, Sporadic	3
20	TT	Female	60	Alzheimer disease, Sporadic	3,9
21	TS	Female	85	Alzheimer disease, Sporadic	2c,2d
22	TS	Male	78	Alzheimer disease, Sporadic	4f,S5a,S5b
23	TS	Female	71	Alzheimer disease, Sporadic	8b
24	TT	Male	61	Alzheimer disease, Sporadic	S4a,S4b,S4c,S4d
25	TT	Female	50	FTLD-TDP43, Hereditary	N/A
26	TT	Female	75	FTLD-TDP43, Hereditary	N/A
27	TT	Female	42	FTLD-TDP43, Hereditary	N/A
28	TT	Female	59	FTLD-TDP43, Hereditary	N/A
29	TT	Male	34	To be determined	N/A
30	TT	Female	66	FTLD-Tau, Sporadic	N/A
31	TT	Male	91	To be determined	N/A
32	TT	Female	58	Alzheimer disease, Sporadic	N/A
33	TT	Male	63	Alzheimer disease, Sporadic	N/A
34	TT	Male	64	Diffuse Lewy body disease	N/A
35	TS	Male	80	Diffuse Lewy body disease	N/A
36	TS	Male	74	To Be Determined	N/A
37	TS	Female	66	FTLD-TDP43, Hereditary	N/A
38	TS	Male	84	To be determined	N/A
39	TS	Female	43	Alzheimer disease, Hereditary	N/A
40	TS	Male	76	To be determined	N/A
41	TS	Female	80	To be determined	N/A
42	TS	Male	59	Alzheimer disease, Sporadic	N/A
43	TS	Female	54	Alzheimer disease, Hereditary	N/A
44	TS	Male	74	To be determined	N/A
45	SS	Female	82	To be determined	N/A
46	SS	Male	79	To be determined	N/A
47	SS	Male	63	Diffuse Lewy body disease	N/A
48	SS	Female	44	Alzheimer disease, Hereditary	N/A

Frontotemporal Lobar Degeneration (FTLD), TAR DNA-binding protein 43 (TDP-43), Granulin (GRN)