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2D and 3D interactions occurred between compounds 2, 2f, 2g and PDB ligand with the Zika virus protease enzyme mutation (PDB: 7LVG). Alky interactions, π-alkyl, π–π stacked (pink dashed line), hydrogen bonding (green dashed line), π–σ (lilac dashed line), π anion interaction (orange dashed line) and Unfavorable interaction (red dashed line). Residues: Tyr (Tyrosine), Ala (Alanine), Gly (Glycine), His (Histidine), Val (Valine), Asp (aspartic acid), Pro (Proline) and Asn (Asparagine).
