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. 2024 Oct 24;9(44):44624–44638. doi: 10.1021/acsomega.4c07148

Table 3. Inhibitory Effects of Part of the Obtained Compounds against ZIKV NS2B/NS3a.

compounds screening at 100 μM (%) screening at 20 μM (%) IC50 (μM)
2a 98 ± 0.5 51 ± 3.4 19.8 ± 0.5
2b 55 ± 2.3 64 ± 2.5 84.9 ± 9.0
2c 48 ± 2.2 25 ± 2.6 >100
2d 53 ± 1.7 25 ± 2.2 92.5 ± 3.1
2e 99 ± 0.2 72 ± 3.1 13.0 ± 0.4
2f 99 ± 0.4 98 ± 1.1 2.7 ± 0.3
2g 97 ± 1.1 99 ± 0.4 1.9 ± 0.1
2h 99 ± 0.2 96 ± 0.4 4.8 ± 0.5
2i NT NT NT
2j 82 ± 2.7 50 ± 3.8 19.7 ± 2.1
2k 100 ± 0.1 86 ± 0.8 6.1 ± 0.6
2l NT NT NT
2m NT NT NT
a

NT: not tested.