Table 3. Inhibitory Effects of Part of the Obtained Compounds against ZIKV NS2B/NS3a.
compounds | screening at 100 μM (%) | screening at 20 μM (%) | IC50 (μM) |
---|---|---|---|
2a | 98 ± 0.5 | 51 ± 3.4 | 19.8 ± 0.5 |
2b | 55 ± 2.3 | 64 ± 2.5 | 84.9 ± 9.0 |
2c | 48 ± 2.2 | 25 ± 2.6 | >100 |
2d | 53 ± 1.7 | 25 ± 2.2 | 92.5 ± 3.1 |
2e | 99 ± 0.2 | 72 ± 3.1 | 13.0 ± 0.4 |
2f | 99 ± 0.4 | 98 ± 1.1 | 2.7 ± 0.3 |
2g | 97 ± 1.1 | 99 ± 0.4 | 1.9 ± 0.1 |
2h | 99 ± 0.2 | 96 ± 0.4 | 4.8 ± 0.5 |
2i | NT | NT | NT |
2j | 82 ± 2.7 | 50 ± 3.8 | 19.7 ± 2.1 |
2k | 100 ± 0.1 | 86 ± 0.8 | 6.1 ± 0.6 |
2l | NT | NT | NT |
2m | NT | NT | NT |
NT: not tested.